Metabólitos secundários e atividade biológica de fungos do gênero Mycena

Abstract

The Mycenaceae family has approximately 700 cataloged species, the genus Mycena is considered the largest genus of the family and has approximately 500 species. Of these species, 68 are bioluminescent, 16 of which are found in Brazil. Fungi of the genus Mycena are mostly bioactive and of chemical-pharmacological interest. Therefore, the objective of this study was to carry out a bibliographical survey on the secondary metabolites and biological activities of fungal species of the genus Mycena. Based on research in Scopus, Scielo, Science Direct and Web of Science databases with no restriction on publication date, through the CAPES Journal Portal. The results showed the existence of 40 articles that reported the biological activity and the isolation of secondary metabolites of fungi of the genus Mycena, totaling 21 species of fungi of the genus Mycena, 8 of which are bioluminescent. The researched articles showed the isolation of 78 secondary metabolites, the main classes of metabolites reported were alkaloids, terpenes (diterpenes and sesquiterpenes), terpenoids, strobilurins, halogenated compounds and polyines. The main biological activities described were: antibiotic, antifungal, cytotoxic, antispasmodic, mutagenic, allelopathic and antimicrobial activity. Given the above, the results obtained in this prospection contributed to the knowledge about the isolation of secondary metabolites of species of the genus Mycena, especially the species of bioluminescent fungi whose study of secondary metabolism is still scarce. In addition, the biological activities of fungi of the Mycena genus are favorable to the pharmaceutical industry due to the range of applications.