Levantamento bibliográfico sobre as contribuições dos complexos metálicos para a Medicina

Abstract

Inorganic Chemistry is an area of Chemistry that studies the compounds of chemical elements other than carbon, called inorganic. Therefore, one of the highlights of this area is Coordination Chemistry, in which it is the inorganic field that studies metal complexes, where scientists analyzed the possibility of these being drug candidates, considering that the coordination of their ligands can cause the complex to present different pharmacological activities, as well as can potentiate the effects of a particular drug. In this sense, the objective of this work was to carry out a bibliographic survey on the pharmacological contributions that metal complexes brought to Medicine based on articles published in the Web of Science database between the years 2011-2021, in which the activity was analyzed. biological, the coordination number, the metallic center and the most recurrent synthetic routes, as well as the molecules in more advanced stages of research. In the database, 317 articles were found, but for a more detailed search, 15 articles were used for analysis. Thus, the results showed that the antitumor pharmacological activity and coordination number 6 is more recurrent among the compounds. The copper metallic center and the reflux system is most used in the syntheses, in addition, four inorganic molecules were found in advanced stages of research, for the treatment of cancer. Thus, with this research it was possible to understand the relevant aspects that made the metallic complexes have an important role in medicine.