AVANÇOS TECNOLÓGICOS NA RADIOTERAPIA ESTEREOTÁXICA NO TRATAMENTO DOS GLIOMAS DE ALTO GRAU

Abstract

High-grade gliomas are among the most aggressive brain tumors and present a poor prognosis, even with the currently available therapeutic advances. In this context, stereotactic radiotherapy (SRT) has emerged as a treatment modality that allows greater precision in dose delivery, reducing exposure to healthy tissues and enhancing tumor control. The advancement of technologies such as adaptive planning, radiomics, dosiomics, and artificial intelligence has expanded the possibilities for personalization of radiotherapy treatment, highlighting the importance of discussing technological advances in stereotactic radiotherapy applied to the treatment of high-grade gliomas. METHODOLOGY: This study consists of na integrative literature review with a qualitative approach, based on scientific articles published between 2023 and 2025. The search was conducted in the PubMed, ScienceDirect, BMC, and OUP Academic databases using descriptors related to stereotactic radiotherapy, high-grade gliomas, and artificial intelligence in oncology. Studies addressing therapeutic efficacy, clinical safety, and technological innovations in radiotherapy were included. RESULTS: The analyzed studies demonstrate that the integration of advanced imaging techniques with machine learning algorithms improves tumor delineation accuracy and radiation dose planning. Moreover, technologies such as MR-Linac enable real-time treatment adaptation, reducing safety margins and minimizing adverse effects without compromising local tumor control. CONCLUSION: The integration of emerging technologies in stereotactic radiotherapy represents a significant advancement in radiation oncology, contributing to safer, more precise, and personalized treatments for patients with high-grade gliomas.