Desenvolvimento e caracterização de biomembranas à base de Cúrcuma Longa l., Quercetina, Hidroxiapatita e Blenda Polimérica para regeneração óssea

Abstract

The use of biocomponents promotes the biological absorption of biomembranes in the body contributing to the regeneration process. The incorporation of Curcuma longa L., (CUR), quercetin (QUER), hydroxyapatite (HAp) in biomembranes favors the osteoingrative capacity, by the mimicking the natural extracellular matrix of bone to enable bone cell attachment and and bone cell proliferation. The biomembranes were prepared by the solvent evaporation process of solvent, favoring good morphology and miscibility in 5 different ratios, B00, B01, B02, B03 and B04, which were homogeneous and smooth. In the process of obtaining the biomembranes it was noted the characteristic band of each biocomposite, suggesting that there was no chemical reaction between the components, keeping, therefore, the phytochemical phytochemical and bioactive compounds were preserved in the formulation of biomembranes. The TG, DSC and XRD of the bioactive components: QUER, CUR and HAp, suggested the purity of these biocomponents. Regarding the diffractometry of the biomembranes, it was noted the miscibility and into the polymeric matrix. In the degree of intumescence, the biomembrane B03 presented a higher stability stability, by demonstrating a G.I of almost 220% in 24h. It was observed in biomembrane B04 showed a constant and progressive loss of mass, showing greater stability in its degradation. degradation. The wetting angle was less than 90° indicating that the material obtained is hydrophilic. All biomembranes (B01, B02, B03 and B04) analyzed showed efficient potential as biomaterial. As biomaterial. In surface tension, all biomembranes showed good adhesion capacity. adhesion capacity. The bioactivity test was performed by evaluating the toxicity through Artemia salina, which confirmed the atoxicity of biomembranes.