Modelagem comparativa e refinamento molecular da enzima fosfo glucosamina mutase do mycobacterium tuberculosis

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dc.contributor.advisor1 Ramos, Ricardo Martins
dc.contributor.advisor1Lattes http://lattes.cnpq.br/1163294951081965pt_BR
dc.creator Costa, Jhonatan Matheus Sousa
dc.creator.Lattes http://lattes.cnpq.br/2284837286838539pt_BR
dc.date.accessioned 2023-06-19T14:29:02Z
dc.date.available 2023-06-19T14:29:02Z
dc.date.issued 2020
dc.description.abstract Tuberculosis (TB) is the leading cause of death from an infectious agent in the world according to the World Health Organization (WHO) and the epidemic is being strengthened by the emergence of Multi and eXtensively Drug Resistant strains (MDR-TB and XDR-TB), decreasing the treatment options that have been used for decades. The GlmM catalyzes the interconversion of glucosamine-6-phosphate (GlcN6P) to glucosamine-1-phosphate (GlcN1P), catalyzing the second step of the biosynthesis process of UDPGlcNAc (uridinediphospho-N-acetylglucosamine) which is essential for the life cycle of Mycobacterium Tuberculosis (MTB). In the present study, comparative modeling and molecular refinement techniques were used to generate a three-dimensional model of MTB GlmM enzyme.pt_BR
dc.description.resumo A tuberculose (TB) é a principal causa de morte por doença infecciosa agente no mundo segundo a Organização Mundial da Saúde (OMS) e a epidemia está sendo fortalecida pelo surgimento de doenças multi e extensivamente Cepas resistentes a medicamentos (MDR-TB e XDR-TB), diminuindo as opções de tratamento usadas há décadas. O GlmM catalisa a interconversão de glucosamina-6-fosfato (GlcN6P) para glucosamina-1-fosfato (GlcN1P), catalisando a segunda etapa do processo de biossíntese de UDPGlcNAc (uridinadifosfo-N-acetilglucosamina) que é essencial para o ciclo de vida do Mycobacterium Tuberculosis (MTB). No presente estudo, a modelagem comparativa e técnicas de refinamento molecular foram usadas para gerar um tridimensional modelo da enzima MTB GlmM.pt_BR
dc.identifier.citation COSTA, Jhonatan Matheus Sousa. Comparative modeling and molecular refinement of the enzyme Phosphoglucosamine mutase from Mycobacterium tuberculosis. Orientador: Ricardo Martins Ramos. 2020. 6 f. Trabalho de Conclusão de Curso (Análise e Desenvolvimento de Sistemas) - Instituto Federal do Piauí, Campus Teresina Central, Teresina, 2020.pt_BR
dc.identifier.uri https://bia.ifpi.edu.br/jspui/handle/123456789/1902
dc.language porpt_BR
dc.publisher Instituto Federal de Educação, Ciência e Tecnologia do Piauípt_BR
dc.publisher.country Brasilpt_BR
dc.publisher.department Campus Teresina Centralpt_BR
dc.publisher.initials IFPIpt_BR
dc.rights Acesso Abertopt_BR
dc.subject Modelagem comparativapt_BR
dc.subject refinamento molecularpt_BR
dc.subject Mycobacterium tuberculosept_BR
dc.subject.cnpq CNPQ::CIENCIAS EXATAS E DA TERRA::CIENCIA DA COMPUTACAOpt_BR
dc.title Modelagem comparativa e refinamento molecular da enzima fosfo glucosamina mutase do mycobacterium tuberculosispt_BR
dc.type Trabalho de Conclusão de Cursopt_BR

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