Síntese e caracterização espectroscópica de complexo de Cu2+ com ligante 4-imidazol ácido carboxílico (4-ImAC)

Abstract

The anticancer properties of cisplatin represent a historic milestone for Medicinal Inorganic Chemistry. However, the side effects to the human body associated with the clinical use of this drug, such as nausea and high toxicity, resulted in the search for the development of new drugs based on metallic compounds with more effective and less harmful effects. Among the transition metals, copper stands out, in view of the various pharmacological and biological applications of copper-based complexes, including antioxidant and antibacterial activity. Therefore, this work aims to synthesize and characterize a Cu II complex containing the ligand 4-imidazole carboxylic acid 4- (ImAC). This is an experimental research, in which the compound obtained was characterized by the techniques of absorption spectroscopy in the Infrared (IR) region, where it was possible to identify, in the final complex, bands referring to the vibrations of the imidazole ligand and Electronic Spectroscopy in the region of Ultraviolet Visible (UV-Vis), where through this it was found that the complex had wide, intense and well defined bands in the visible region, which are attributed to the charge transfer transitions from the metal to the ligand (MLCT) . In addition, the optical behavior of the coordination compound was verified from the luminescent emission in the region of 686 nm, which was only possible because of the coordination of the metal with the ligand