Análise e aplicabilidade de um compósito a base de hidroxiapatita, nanotubos de carbono e polihidroxibutirato

Abstract

Calcium phosphate composites associated with polymers have osteoinductive characteristics, low degradation and improved molding to meet the physical requirements of the bone defect site. Given the potential of Nanohydroxyapatite (nHAP), Carbon Nanotubes (NTC) and Polyhydroxybutyrate (PHB) in bone tissue engineering, the objective was to prepare and characterize a composite based on HAP, NTC and PHB. For this purpose, the samples were analyzed by X-ray Fluorescence, Analytical Thermogravimetry (TGA) and Scanning Electron Microscopy (SEM), toxicity determination, by the Artemia salina test and to test the bactericidal potential of the membranes by the disc diffusion. TGA results show that the material has good thermal stability and predominant PHB characteristics. The chemical composition of the samples, revealed by FRX, is predominant of Calcium and Phosphorus, with insignificant percentage of transition metal impurities. Regarding the microstructural characteristics, it was observed by SEM the presence of pores, low HPA densification and good dispersion of a small amount of NTC. The composite also revealed low toxicity and bactericidal activity for S. aures and E. coli strains. The data obtained demonstrate the potential of the composite for use as bioticides.